Sulfuryl chloride → HCID 13558267, compound

HRID 637568Notes

Reaction equation

HRID 637568 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[CH:8][CH:7]=1)(=[O:3])[CH3:2].S(Cl)([Cl:21])(=O)=O.[Cl-].[Al+3].[Cl-].[Cl-]>>[Cl:21][C:10]1[CH:11]=[C:6]([CH2:5][NH:4][C:1](=[O:3])[CH3:2])[CH:7]=[CH:8][C:9]=1[CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15]

Participants

4

Reactant 3

HCID 24648Sulfuryl chlorideHCID 6451240Aluminum(III) ChlorideHCID 14218727HCID 14218727, compound

Product 1

HCID 13558267HCID 13558267, compound

Procedure

Methyl 3-(4-acetylaminomethylphenyl)propionate (5.00 g, 21.25 mmol) was added to a sulfuryl chloride (85 ml) solution of anhydrous aluminum chloride (14.2 g, 106 mmol) at -25° C. Thereafter, the temperature of the mixture was gradually elevated to 5° C., at which temperature the mixture was subjected to reaction under agitation for 24 hours.

Workup

  1. customwas gradually elevated to 5° C., at which temperature
  2. customwas subjected to reaction under agitation for 24 hours

Sources & evidence

ORD record
ord-c763db7efeff4319a768cca0e10e1e9d
Source dataset
uspto-grants-1985_12
Patent number
US04556735

Reaction notes

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