反应详情

温度

70 °C

A mixture of 11.1 g (40 mmol) of 1,5-dichloro-9,10-anthracenedione, 13.1 g (110 mmol) of 2-[(hydrazinoethyl)amino]ethanol, 4 g of anhydrous potassium bicarbonate, 1 g of anhydrous potassium fluoride, and 110 ml of dimethyl sulfoxide is stirred at 70° C. overnight. The mixture is chilled and the solids are collected by filtration, washed with water, then thoroughly with acetonitrile to give a residue that is crystallized from 2-propanol to leave 2.6 g of product. The hydrochloride salt is prepared as described in Example 3; mp 272°-273° C. (decomposition).

1. temperatureThe mixture is chilled
2. filtrationthe solids are collected by filtration
3. washwashed with water
4. customthoroughly with acetonitrile to give a residue that
5. customis crystallized from 2-propanol