反应详情

To a mixture of 1.50 g (0.0055 mol) of 4-(2,4-dichlorobenzoyl)-1-methyl-5-hydroxypyrazole, 0.56 g (0.0055 mol) of triethylamine and 30 ml of benzene was added 1.03 g (0.0061 mol) of benzyl bromide and the resulting mixture was heated under reflux for 2 hours with stirring. After cooling, precipitated triethyl amine hydrobromide was filtered off. The filtrate was concentrated under reduced pressure and was subjected to column chromatography (silica gel, using ethyl acetate/benzene 1:3 as an eluent) to give 1.79 g of the title compound 4-(2,4-dichlorobenzoyl)-1-methyl-5-benzyloxypyrazole (yield: 93%).

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 2 hours
3. temperatureAfter cooling
4. customprecipitated triethyl amine hydrobromide
5. filtrationwas filtered off
6. concentrationThe filtrate was concentrated under reduced pressure