Methyl iodide → HCID 86740541, compound

HRID 637608Notes

Reaction equation

HRID 637608 reaction equation
[CH:1]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:3]([NH:4][C:5]3=[S:12])[CH2:2]1)[CH2:9]2.[CH3:13][I:14]>CO>[IH:14].[CH3:13][S:12][C:5]1[CH:6]2[CH2:11][CH:1]3[CH2:9][CH:8]([CH2:10][CH:3]([CH2:2]3)[N:4]=1)[CH2:7]2

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13560321HCID 13560321, compound

Product 1

HCID 86740541HCID 86740541, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of the 5-thione derivative 5c (1.45 gram, 8 mmol) and methyl iodide (1.21 gram, 8.5 mmol) in 100 ml methanol was refluxed for 6 hours. The solvent was evaporated to dryness leaving the hydroiodide salt 6 (2 grams) as a white solid. Melting point 235°-238° C. (recrystallized from absolute ethanol).

Workup

  1. temperaturewas refluxed for 6 hours
  2. customThe solvent was evaporated to dryness

Sources & evidence

ORD record
ord-f066f58688db4afdac34d74fc0563a08
Source dataset
uspto-grants-1985_12
Patent number
US04557865

Reaction notes

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