反应详情

5 mg of platinum oxide are added to a solution of 250 mg (1.00 mmole) of crude 5-chloro-2-hydroxy-6-(piperidin-1-yl)-2,3-dihydrobenzofuran in 5 ml of absolute ethanol and the whole is hydrogenated at room temperature and 3 atmospheres. The catalyst is filtered off and the filtrate is concentrated in a vacuum rotary evaporator. The residue is chromatographed over silica gel using methylene chloride as eluant. Recrystallisation from petroleum ether yields 5-chloro-6-(piperidin-1-yl)-2,3-dihydrobenzofuran having a melting point of 38°-40°.

1. customis hydrogenated at room temperature
2. filtrationThe catalyst is filtered off
3. concentrationthe filtrate is concentrated in a vacuum rotary evaporator
4. customThe residue is chromatographed over silica gel
5. customRecrystallisation from petroleum ether