5-Chloro-2-hydroxy-6-(piperidin-1-yl)-2,3-dihydrobenzofuran → 5-Chloro-6-(piperidin-1-yl)-2,3-dihydrobenzofuran

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Reaction Steps

5 mg of platinum oxide are added to a solution of 250 mg (1.00 mmole) of crude 5-chloro-2-hydroxy-6-(piperidin-1-yl)-2,3-dihydrobenzofuran in 5 ml of absolute ethanol and the whole is hydrogenated at room temperature and 3 atmospheres. The catalyst is filtered off and the filtrate is concentrated in a vacuum rotary evaporator. The residue is chromatographed over silica gel using methylene chloride as eluant. Recrystallisation from petroleum ether yields 5-chloro-6-(piperidin-1-yl)-2,3-dihydrobenzofuran having a melting point of 38°-40°.

Provenance & Evidence