Methylamine → 5-Thiazolecarboxamide, 2-(3,4-dimethoxyphenyl)-N,4-dimethyl-

Participants

Reaction Steps

Into a mixed solvent of 80 ml of 40% methylamine and 600 ml of ethanol, 15.4 g of ethyl 2-(3,4-dimethoxyphenyl)-4-methylthiazole-5-carboxylate was dissolved, and then, in a similar manner as in Example 1, the object is obtained as colourless aciculate melting at 181.5° to 183° C. in an amount of 9.6 g corresponding to the yield of 66%.

Provenance & Evidence