Methylamine → 5-Thiazolecarboxamide, 2-(3,4-dimethoxyphenyl)-N,4-dimethyl-

HRID 637707Notes

Reaction equation

HRID 637707 reaction equation
[CH3:1][NH2:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[S:14][C:15]([C:19]([O:21]CC)=O)=[C:16]([CH3:18])[N:17]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]>C(O)C>[CH3:18][C:16]1[N:17]=[C:13]([C:7]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:5]([O:4][CH3:3])[CH:6]=2)[S:14][C:15]=1[C:19]([NH:2][CH3:1])=[O:21]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 2763628ethyl 2-(3,4-dimethoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Product 1

HCID 30680705-Thiazolecarboxamide, 2-(3,4-dimethoxyphenyl)-N,4-dimethyl-Yield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into a mixed solvent of 80 ml of 40% methylamine and 600 ml of ethanol, 15.4 g of ethyl 2-(3,4-dimethoxyphenyl)-4-methylthiazole-5-carboxylate was dissolved, and then, in a similar manner as in Example 1, the object is obtained as colourless aciculate melting at 181.5° to 183° C. in an amount of 9.6 g corresponding to the yield of 66%.

Workup

  1. customin a similar manner as in Example 1, the object is obtained as colourless aciculate melting at 181.5° to 183° C. in an amount of 9.6 g corresponding to the yield of 66%

Sources & evidence

ORD record
ord-4bb6fafd10a74817a999ee992721fd1a
Source dataset
uspto-grants-1985_12
Patent number
US04558059

Reaction notes

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