Methylamine → 5-Thiazolecarboxamide, N,4-dimethyl-2-(2-methoxyphenyl)-

HRID 637709Notes

Reaction equation

HRID 637709 reaction equation
[CH3:1][NH2:2].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[S:12][C:13]([C:17]([O:19]CC)=O)=[C:14]([CH3:16])[N:15]=1>C(O)C>[CH3:16][C:14]1[N:15]=[C:11]([C:6]2[C:5]([O:4][CH3:3])=[CH:10][CH:9]=[CH:8][CH:7]=2)[S:12][C:13]=1[C:17]([NH:2][CH3:1])=[O:19]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 13576837Ethyl 4-Methyl-2-(2-methoxyphenyl)thiazole-5-carboxylate

Product 1

HCID 30680735-Thiazolecarboxamide, N,4-dimethyl-2-(2-methoxyphenyl)-Yield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into a mixed solvent of 80 ml of 40% methylamine and 600 ml of ethanol, 13.9 g of ethyl 2-(2-methoxyphenyl)-4-methylthiazole-5-carboxylate was dissolved. Then, in a similar manner in Example 1, the object was obtained as colourless aciculate melting at 167.5° to 168.5° C. in an amount of 9.4 g corresponding to the yield of 72%.

Workup

  1. customThen, in a similar manner in Example 1, the object was obtained as colourless aciculate melting at 167.5° to 168.5° C. in an amount of 9.4 g corresponding to the yield of 72%

Sources & evidence

ORD record
ord-d9153d89df5741fd89027c44178ede3c
Source dataset
uspto-grants-1985_12
Patent number
US04558059

Reaction notes

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