Hydrochloric Acid → HCID 13393277, compound

HRID 637712Notes

Reaction equation

HRID 637712 reaction equation
[ClH:1].[CH3:2][S:3]([NH:6][C:7]1[CH:8]=[C:9]([CH:21]([OH:44])[CH2:22][NH:23][C:24]([CH3:43])([CH3:42])[CH2:25][CH2:26][N:27]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([N+:38]([O-])=O)=[CH:34][CH:33]=3)[C:28]2=[O:41])[CH:10]=[CH:11][C:12]=1[O:13]CC1C=CC=CC=1)(=[O:5])=[O:4].Cl>CO.[Pd]>[ClH:1].[CH3:2][S:3]([NH:6][C:7]1[CH:8]=[C:9]([CH:21]([OH:44])[CH2:22][NH:23][C:24]([CH3:42])([CH3:43])[CH2:25][CH2:26][N:27]2[CH2:31][CH2:30][N:29]([C:32]3[CH:33]=[CH:34][C:35]([NH2:38])=[CH:36][CH:37]=3)[C:28]2=[O:41])[CH:10]=[CH:11][C:12]=1[OH:13])(=[O:4])=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 20255868HCID 20255868, compound

Product 1

HCID 13393277HCID 13393277, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×

Procedure

A solution of 3.7 g of 1-(3-methanesulfonamido-4-benzyloxyphenyl)-2-{1,1-dimethyl-3-[3-(4-nitrophenyl)-imidazolidin-2-on-1-yl]-propylamino}-ethanol hydrochloride in 250 ml of methanol was mixed with 0.2 g of HCl in 10 ml of methanol and, after addition of 0.7 g of 5% palladium/charcoal, the mixture was hydrogenated at 26° C. and under normal pressure. The resulting solution, freed from the catalyst, was evaporated, and the title compound was obtained with a yield of 3.3 g. After recrystallization from methanol the melting point was 225° C.

Workup

  1. customwas hydrogenated at 26° C. and under normal pressure
  2. customwas evaporated

Sources & evidence

ORD record
ord-8cc2ab85484a4af18c504a8da39bf0ca
Source dataset
uspto-grants-1985_12
Patent number
US04558061

Reaction notes

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