Potassium Carbonate → HCID 13578745, compound

HRID 637777Notes

Reaction equation

HRID 637777 reaction equation
Cl.Cl.[O:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH:4]1[CH:13]([OH:33])[CH2:14][N:15]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]([NH:24][C:25]2[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:32])=[O:23])[CH2:17][CH2:16]1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[O:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH:4]1[CH:13]([OH:33])[CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:21][C:22]([NH:24][C:25]2[C:26]([CH3:32])=[CH:27][CH:28]=[CH:29][C:30]=2[CH3:31])=[O:23])[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 202560091-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine 2HCl

Product 1

HCID 13578745HCID 13578745, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 1-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine 2HCl suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 1-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-48b5998e6fe847659f78030218f5e2de
Source dataset
uspto-grants-1985_12
Patent number
US04558129

Reaction notes

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