huagongshe.com
HRID637779

反应详情

EQUATION

反应方程式

HRID 637779 的结构方程式

REACTANTS

反应物

2
结构：[NH4+].[OH-]
HCID14923

Ammonium hydroxide

H5NO

结构：Cc1cccc(C)c1NC(=O)CN1CCN(CCC2COc3ccccc3O2)CC1.Cl.Cl
HCID70487568

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cccc(C)c1NC(=O)CN1CCN(CC(O)C2COc3ccccc3O2)CC1
HCID13578745

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of 3.5 g of 1-[2-(1,4-benzodioxan-2-yl)ethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt in water (50 ml) is adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride is evaporated to afford 3 g of 1-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine as the free base.

WORKUP

后处理

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride is evaporated