Ammonium Hydroxide → HCID 13578745, compound

HRID 637779Notes

Reaction equation

HRID 637779 reaction equation
Cl.Cl.[O:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH:4]1[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]([NH:24][C:25]2[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:32])=[O:23])[CH2:17][CH2:16]1.[OH-:33].[NH4+]>O>[O:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH:4]1[CH:13]([OH:33])[CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:21][C:22]([NH:24][C:25]2[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:32])=[O:23])[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 704875681-[2-(1,4-Benzodioxan-2-yl)ethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt

Product 1

HCID 13578745HCID 13578745, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3.5 g of 1-[2-(1,4-benzodioxan-2-yl)ethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt in water (50 ml) is adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride is evaporated to afford 3 g of 1-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine as the free base.

Workup

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride is evaporated

Sources & evidence

ORD record
ord-be1223e073da48a59953d380a7859130
Source dataset
uspto-grants-1985_12
Patent number
US04558129

Reaction notes

Loading…