Isopropylamine → HCID 86051412, compound

HRID 637833Notes

Reaction equation

HRID 637833 reaction equation
BrCCC1C([Cl:10])=CC(Cl)=[CH:6][C:5]=1[O:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[C:14]=1CCBr.[CH:24]([NH2:27])([CH3:26])[CH3:25]>C(Cl)(Cl)Cl>[ClH:10].[Cl:19][C:17]1[CH:18]=[C:13]([CH:14]=[C:15]([Cl:20])[CH:16]=1)[O:12][CH2:5][CH2:6][NH:27][CH:24]([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 86739921HCID 86739921, compound

Product 1

HCID 86051412HCID 86051412, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following the procedure of Preparation 1, 2-bromoethyl-3,5-dichlorophenyl ether and isopropyl amine were reacted in refluxing chloroform overnight to yield an oil, the free base of the title compound. Thereafter, a portion of the oil was reacted with ethereal hydrogen chloride to form the hydrochloride salt in 43.4% yield, m.p. 195°-197° C.

Workup

  1. customwere reacted
  2. customto yield an oil

Sources & evidence

ORD record
ord-6e185538399e48e6b66a3fb12e003670
Source dataset
uspto-grants-1985_12
Patent number
US04558155

Reaction notes

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