Isopropylamine → HCID 20256305, compound

HRID 637844Notes

Reaction equation

HRID 637844 reaction equation
BrCCC1C(Cl)=[C:6]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13](CCBr)[C:12]=2[Cl:20])[CH:7]=CC=1.[CH:22]([NH2:25])([CH3:24])[CH3:23]>>[ClH:20].[Cl:20][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[O:10][CH2:6][CH2:7][NH:25][CH:22]([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 86739923HCID 86739923, compound

Product 1

HCID 20256305HCID 20256305, compound

Procedure

Following the procedure of Example 11, 2-bromoethyl-2-chlorophenyl ether was reacted with isopropyl amine (excess) and the reaction mixture processed to give an oil, the free base of the title compound. A portion of the oil was reacted with ethereal hydrogen chloride and the hydrochloride salt recrystallized from methanol-diethyl ether, m.p. 118°-119.5° C. (75%).

Workup

  1. customto give an oil

Sources & evidence

ORD record
ord-c6bcdc7610a54f9db6ee91ea61058637
Source dataset
uspto-grants-1985_12
Patent number
US04558155

Reaction notes

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