反应详情

In an ice bath, 29.8 g of pivaloyl chloride (226 mmol) was added dropwise to a solution of compound 5 (50.0 g, 207 mmol) and triethylamine (37.9 mL) in dichloromethane (300.0 mL) within one hour and then stirred for 2 hours until the starting materials disappeared. 150 mL of water was added into the reaction solution and stirred at room temperature for 10 minutes. The organic layer was separated, dried over anhydrous sodium sulfate, concentrated, and separated through a short column with ethyl acetate to give white solid (57.7 g, 85.6%).

1. stirringstirred at room temperature for 10 minutes
2. customThe organic layer was separated
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customseparated through a short column with ethyl acetate