Sodium borohydride → HCID 13191369, compound

Participants

Reaction Steps

A solution of 0.87 g (0.0229 mol) of sodium borohydride in 20 ml of water was added dropwise to a suspension of 10 g (0.0328 mol) of 4,4-dimethyl-1-phenylsulphonyl-2-(1,2,4-triazol-1-yl)-pentan-3-one (obtained as described in Example 4) and 2.42 g (0.0221 mol) of calcium chloride in 150 ml of isopropanol at -10° C. After 18 hours, the reaction mixture was worked up according to Example 3. 7 g (68.6% of theory) of 4,4-dimethyl-1-phenylsulphonyl-2-(1,2,4-triazol-1-yl)-pentan-3-ol of melting point 145° C. were obtained.

Provenance & Evidence