Sodium borohydride → HCID 13191369, compound

HRID 637867Notes

Reaction equation

HRID 637867 reaction equation
[BH4-].[Na+].[CH3:3][C:4]([CH3:24])([CH3:23])[C:5](=[O:22])[CH:6]([N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)[CH2:7][S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])=[O:9].[Cl-].[Ca+2].[Cl-]>O.C(O)(C)C>[CH3:3][C:4]([CH3:24])([CH3:23])[CH:5]([OH:22])[CH:6]([N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)[CH2:7][S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])=[O:9]

Participants

6

Reactant 3

HCID 4311764Sodium borohydrideHCID 5284359Calcium ChlorideHCID 13191368HCID 13191368, compound

Product 1

HCID 13191369HCID 13191369, compoundYield 68.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

A solution of 0.87 g (0.0229 mol) of sodium borohydride in 20 ml of water was added dropwise to a suspension of 10 g (0.0328 mol) of 4,4-dimethyl-1-phenylsulphonyl-2-(1,2,4-triazol-1-yl)-pentan-3-one (obtained as described in Example 4) and 2.42 g (0.0221 mol) of calcium chloride in 150 ml of isopropanol at -10° C. After 18 hours, the reaction mixture was worked up according to Example 3. 7 g (68.6% of theory) of 4,4-dimethyl-1-phenylsulphonyl-2-(1,2,4-triazol-1-yl)-pentan-3-ol of melting point 145° C. were obtained.

Sources & evidence

ORD record
ord-48f3e342d5fa4e8c9b4342bf3744c87f
Source dataset
uspto-grants-1985_12
Patent number
US04559077

Reaction notes

Loading…