Ethyl isocyanate → 1-Ethyl-3-[4-(6-(dimethylaminomethyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)phenyl]urea

HRID 63793Notes

Reaction equation

HRID 63793 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:11]3=[CH:20][C:21]([CH2:23][N:24]([CH3:26])[CH3:25])=[CH:22][N:10]3[N:9]=2)=[CH:4][CH:3]=1.[CH2:27]([N:29]=[C:30]=[O:31])[CH3:28]>ClCCl>[CH2:27]([NH:29][C:30]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[C:11]3=[CH:20][C:21]([CH2:23][N:24]([CH3:26])[CH3:25])=[CH:22][N:10]3[N:9]=2)=[CH:4][CH:3]=1)=[O:31])[CH3:28]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 117987912HCID 117987912, compound

Product 1

HCID 725483831-Ethyl-3-[4-(6-(dimethylaminomethyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)phenyl]urea

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 13a (0.15 mmol) was dissolved in 10 mL of anhydrous dichloromethane, and 3 equiv of ethyl isocyanate was added and stirred at room temperature overnight. The target compound was obtained by filtration.

Workup

  1. customThe target compound was obtained by filtration

Sources & evidence

ORD record
ord-88fec49bf0194ab695331aee6878ea20
Source dataset
uspto-grants-2016_09
Patent number
US09447101B2

Reaction notes

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