Dimethylamine → HCID 86740556, compound

HRID 637935Notes

Reaction equation

HRID 637935 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[S:11])[N:3]=1.[CH3:15][NH:16][CH3:17]>C(#N)C>[Cl:8][C:6]1[CH:7]=[C:2]([N:16]([CH3:17])[CH3:15])[N:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[S:11])[N:5]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 54036785HCID 54036785, compound

Product 1

HCID 86740556HCID 86740556, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
0 °C

Procedure

A solution of ethyl 4,6-dichloro-2-pyrimidinylthioacetate (6 g) in acetonitrile (25 ml) is treated with a 33% aqueous solution of dimethylamine (6.4 ml). The mixture is left to stand at room temperature for 1 hour, then is cooled for 2 hours at 0° C. The precipitate is filtered, washed with a small quantity of acetonitrile: 4.85 g of the desired product are obtained (III, 29).

Workup

  1. waitThe mixture is left
  2. filtrationThe precipitate is filtered
  3. washwashed with a small quantity of acetonitrile

Sources & evidence

ORD record
ord-b3632ff075414039b7da6d4b1ba4c10b
Source dataset
uspto-grants-1985_12
Patent number
US04559345

Reaction notes

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