反应详情

To a suspension of 2-p-methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine (8 g; see example 5) in trifluoroacetic acid (80 ml) anisole (2,7 ml) is added and the mixture is refluxed for 50'. After cooling, the trifluoroacetic acid is evaporated. The residue is dissolved in ethyl ether and the separated solid is filtered, washed with ethyl ether, then with water to neutrality, with cool acetone and again with ethyl ether. 5 G of the desired product (III, 33) are obtained.

1. additionis added
2. temperaturethe mixture is refluxed for 50'
3. temperatureAfter cooling
4. customthe trifluoroacetic acid is evaporated
5. dissolutionThe residue is dissolved in ethyl ether
6. filtrationthe separated solid is filtered
7. washwashed with ethyl ether