Formamidine → 5-ethyl-1,6-naphthyridin-2(1H)-one

HRID 637978Notes

Reaction equation

C[N:2](C)[CH:3]=[CH:4][C:5]1[NH:10][C:9](=[O:11])[CH:8]=[CH:7][C:6]=1[C:12](=O)[CH2:13][CH3:14].C(N)=N.C([O-])(=O)C.[NH4+]>>[CH2:13]([C:12]1[N:2]=[CH:3][CH:4]=[C:5]2[C:6]=1[CH:7]=[CH:8][C:9](=[O:11])[NH:10]2)[CH3:14]

Participants

Reactant 3

HCID 68047Formamidine

HCID 517165Ammonium Acetate

HCID 537092406-[2-(Dimethylamino)ethenyl]-5-propanoylpyridin-2(1H)-one

Product 1

HCID 132320505-ethyl-1,6-naphthyridin-2(1H)-one

Procedure

The process according to claim 12 which comprises reacting 6-(2-dimethylaminoethenyl)-5-(n-propanoyl)-2(1H)-pyridinone with formamidine or ammonium acetate to produce 5-ethyl-1,6-naphthyridin-2(1H)-one.

Sources & evidence

ORD record: ord-602be63d9b7143c4a4fad5c36e21f8fc
Source dataset: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04559347

Reaction notes

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