Epichlorohydrin → HCID 20255091, compound

HRID 638032Notes

Reaction equation

HRID 638032 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[N:3]=1.[CH2:16]([CH:18]1[O:20][CH2:19]1)Cl.C(=O)([O-])[O-].[K+].[K+]>>[CH3:8][C:6]1[CH:7]=[C:2]([CH3:1])[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH:18]3[O:20][CH2:19]3)=[CH:11][CH:10]=2)[N:5]=1

Participants

4

Reactant 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 136102958HCID 136102958, compound

Product 1

HCID 20255091HCID 20255091, compound

Procedure

4,6-dimethyl-2-(4-hydroxyphenyl)-pyrimidine is reacted with epichlorohydrin in the presence of potassium carbonate analogously to Example 5b). After working up, 4,6-dimethyl-2-[4-(2,3-epoxypropoxy)-phenyl]-pyrimidine is obtained which, after recrystallisation from isopropanol, has a melting point of 88°-90°.

Sources & evidence

ORD record
ord-c69157e22b664d1196b6045063214d40
Source dataset
uspto-grants-1985_12
Patent number
US04559354

Reaction notes

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