HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Biphenyl-4-yloxy)-2,3-epoxypropane → 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-(4-biphenyloxy)-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Biphenyl-4-yloxy)-2,3-epoxypropane | HCID 107325 | — |
| Reactant | 5-[2-(Benzylamino)-ethoxy]-salicylamide | HCID 13754419 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-(4-biphenyloxy)-2-propanol | HCID 20255161 | — |
Reaction Steps
A solution of 5.97 g of 4-(2,3-epoxypropoxy)-biphenyl and 6.87 g of 5-[2-(benzylamino)-ethoxy]-salicylamide in 140 ml of isopropanol is heated under reflux for 15 hours and the solvent is then removed in a rotary evaporator. The residue is recrystallised from diethyl ether, yielding 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-(4-biphenyloxy)-2-propanol having a melting point of 135°-138°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04559354 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-3dce6523b40644ecb789251b56f6870c |
| Source note | uspto-grants-1985_12 |