HRID638037

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID107325

2-{[([1,1'-Biphenyl]-4-yl)oxy]methyl}oxirane

C15H14O2

HCID13754419

未命名化合物

PRODUCTS

生成物

结构：NC(=O)c1cc(OCCN(Cc2ccccc2)CC(O)COc2ccc(-c3ccccc3)cc2)ccc1O

HCID20255161

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A solution of 5.97 g of 4-(2,3-epoxypropoxy)-biphenyl and 6.87 g of 5-[2-(benzylamino)-ethoxy]-salicylamide in 140 ml of isopropanol is heated under reflux for 15 hours and the solvent is then removed in a rotary evaporator. The residue is recrystallised from diethyl ether, yielding 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-(4-biphenyloxy)-2-propanol having a melting point of 135°-138°.

WORKUP

后处理

temperatureunder reflux for 15 hours
customthe solvent is then removed in a rotary evaporator
customThe residue is recrystallised from diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3dce6523b40644ecb789251b56f6870c
来源数据集: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04559354
来源说明: uspto-grants-1985_12

反应 SMILES

[O:1]1[CH2:17][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1.[CH2:18]([NH:25][CH2:26][CH2:27][O:28][C:29]1[CH:37]=[C:33]([C:34]([NH2:36])=[O:35])[C:32]([OH:38])=[CH:31][CH:30]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)(C)C>[CH2:18]([N:25]([CH2:26][CH2:27][O:28][C:29]1[CH:30]=[CH:31][C:32]([OH:38])=[C:33]([C:34](=[O:35])[NH2:36])[CH:37]=1)[CH2:17][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1