HCID 20255139, compound → HCID 20255123, compound

HRID 638038Notes

Reaction equation

HRID 638038 reaction equation
C([N:8]([CH2:26][CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([O:35]CC2C=CC=CC=2)=[C:31]([C:43](=[O:45])[NH2:44])[CH:30]=1)[CH2:9][CH:10]([OH:25])[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:20]([CH3:24])[CH:21]=[CH:22][N:23]=2)=[CH:15][CH:14]=1)C1C=CC=CC=1>CO>[C:43]([C:31]1[CH:30]=[C:29]([CH:34]=[CH:33][C:32]=1[OH:35])[O:28][CH2:27][CH2:26][NH:8][CH2:9][CH:10]([OH:25])[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[N:20]([CH3:24])[CH:21]=[CH:22][N:23]=2)=[CH:17][CH:18]=1)(=[O:45])[NH2:44]

Participants

3

Reactant 1

HCID 20255139HCID 20255139, compound

Product 1

HCID 20255123HCID 20255123, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.85 g of crude 1-[N-benzyl-2-(3-carbamoyl-4-benzyloxyphenoxy)-ethylamino]-3-[4-[1-methyl-1H-imidazol-2-yl]-phenoxy]-2-propanol in 10 ml of methanol is hydrogenated analogously to Example 8. After working up, the 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(1-methyl-1H-imidazol-2-yl)-phenoxy]-2-propanol having a melting point of 108°-112° is obtained.

Sources & evidence

ORD record
ord-77e27092751f47c2aaaa198503beabb4
Source dataset
uspto-grants-1985_12
Patent number
US04559354

Reaction notes

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