HCID 20255191, compound → HCID 20255126, compound

HRID 638043Notes

Reaction equation

HRID 638043 reaction equation
C([N:8]([CH2:30][CH2:31][O:32][C:33]1[CH:38]=[CH:37][C:36]([OH:39])=[C:35]([C:40](=[O:42])[NH2:41])[CH:34]=1)[CH2:9][CH:10]([OH:29])[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:23]([CH3:24])[N:22]=[C:21]([S:25]([CH3:28])(=[O:27])=[O:26])[N:20]=2)=[CH:15][CH:14]=1)C1C=CC=CC=1>O1CCOCC1>[C:40]([C:35]1[CH:34]=[C:33]([CH:38]=[CH:37][C:36]=1[OH:39])[O:32][CH2:31][CH2:30][NH:8][CH2:9][CH:10]([OH:29])[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[N:23]([CH3:24])[N:22]=[C:21]([S:25]([CH3:28])(=[O:27])=[O:26])[N:20]=2)=[CH:17][CH:18]=1)(=[O:42])[NH2:41]

Participants

3

Reactant 1

HCID 20255191HCID 20255191, compound

Product 1

HCID 20255126HCID 20255126, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

24.3 g of crude 1-[N-benzyl-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]]-3-[4-(1-methyl-3-methylsulphonyl-1H-1,2,4-triazol-5-yl)-phenoxy]-2-propanol are catalytically debenzylated analogously to Example (4) and for working up, the crystalline precipitate is dissolved in dioxan by heating. Recrystallisation from methanol/dioxan yields 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(1-methyl-3-methylsulphonyl-1H-1,2,4-triazol-5-yl)-phenoxy]-2-propanol having a melting point of 190°-191°.

Workup

  1. temperatureby heating
  2. customRecrystallisation from methanol/dioxan

Sources & evidence

ORD record
ord-374eece45ae149f0a31f1515a7d641ab
Source dataset
uspto-grants-1985_12
Patent number
US04559354

Reaction notes

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