5-[4-(2,3-epoxypropoxy)-phenyl]-2-methyl-2H-tetrazole → 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(2-methyl-2H-tetrazol-5-yl)-phenoxy]-2-propanol

HRID 638044Notes

Reaction equation

HRID 638044 reaction equation
[O:1]1[CH2:17][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[N:13][N:14]([CH3:16])[N:15]=2)=[CH:7][CH:6]=1.[NH2:18][CH2:19][CH2:20][O:21][C:22]1[CH:30]=[C:26]([C:27]([NH2:29])=[O:28])[C:25]([OH:31])=[CH:24][CH:23]=1>O1CCOCC1>[C:27]([C:26]1[CH:30]=[C:22]([CH:23]=[CH:24][C:25]=1[OH:31])[O:21][CH2:20][CH2:19][NH:18][CH2:17][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[N:13][N:14]([CH3:16])[N:15]=2)=[CH:7][CH:6]=1)(=[O:28])[NH2:29]

Participants

4

Reactant 2

HCID 202551585-[4-(2,3-epoxypropoxy)-phenyl]-2-methyl-2H-tetrazoleHCID 230496945-(2-Aminoethoxy)-2-hydroxybenzamide

Product 1

HCID 202551711-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(2-methyl-2H-tetrazol-5-yl)-phenoxy]-2-propanol

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Analogously to the procedure described in Example 12, by reacting 2.3 g of 5-[4-(2,3-epoxypropoxy)-phenyl]-2-methyl-2H-tetrazole with 1.5 g of 5-(2-aminoethoxy)-salicylamide there is obtained 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(2-methyl-2H-tetrazol-5-yl)-phenoxy]-2-propanol having a melting point of 174°-175° (from dioxan).

Sources & evidence

ORD record
ord-a08ace68275a4c3f9d157f6675173bc1
Source dataset
uspto-grants-1985_12
Patent number
US04559354

Reaction notes

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