HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[4-(2,3-epoxypropoxy)-phenyl]-2-methyl-2H-tetrazole → 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(2-methyl-2H-tetrazol-5-yl)-phenoxy]-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[4-(2,3-epoxypropoxy)-phenyl]-2-methyl-2H-tetrazole | HCID 20255158 | — |
| Reactant | 5-(2-Aminoethoxy)-2-hydroxybenzamide | HCID 23049694 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(2-methyl-2H-tetrazol-5-yl)-phenoxy]-2-propanol | HCID 20255171 | — |
Reaction Steps
Analogously to the procedure described in Example 12, by reacting 2.3 g of 5-[4-(2,3-epoxypropoxy)-phenyl]-2-methyl-2H-tetrazole with 1.5 g of 5-(2-aminoethoxy)-salicylamide there is obtained 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(2-methyl-2H-tetrazol-5-yl)-phenoxy]-2-propanol having a melting point of 174°-175° (from dioxan).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04559354 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-a08ace68275a4c3f9d157f6675173bc1 |
| Source note | uspto-grants-1985_12 |