5-[2-(Benzylamino)-ethoxy]-salicylamide → HCID 20255111, compound

HRID 638057Notes

Reaction equation

HRID 638057 reaction equation
[O:1]1[CH2:20][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=2)=[CH:7][CH:6]=1.[CH2:21]([NH:28][CH2:29][CH2:30][O:31][C:32]1[CH:40]=[C:36]([C:37]([NH2:39])=[O:38])[C:35]([OH:41])=[CH:34][CH:33]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(O)(C)C>[CH2:21]([N:28]([CH2:29][CH2:30][O:31][C:32]1[CH:33]=[CH:34][C:35]([OH:41])=[C:36]([C:37](=[O:38])[NH2:39])[CH:40]=1)[CH2:20][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=2)=[CH:7][CH:6]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 137544195-[2-(Benzylamino)-ethoxy]-salicylamideHCID 20255152HCID 20255152, compound

Product 1

HCID 20255111HCID 20255111, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 7.0 g of 2-[4-(2,3-epoxypropoxy)-phenyl]-4-(trifluoromethyl)-thiazole and 6.01 g of 5-[2-(benzylamino)-ethoxy]-salicylamide in 150 ml of isopropanol is heated under reflux for 18 hours and the solvent is subsequently removed in a rotary evaporator. The 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-[4-(trifluoromethyl)-thiazol-2-yl]-phenoxy]-2-propanol, obtained in the form of an oil, is further processed in that form.

Workup

  1. temperatureunder reflux for 18 hours
  2. customthe solvent is subsequently removed in a rotary evaporator

Sources & evidence

ORD record
ord-92343b321dae4b49b84f1a06c1521a1c
Source dataset
uspto-grants-1985_12
Patent number
US04559354

Reaction notes

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