反应详情

A mixture of 10.0 g of 4-chloromethyl-6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl]isoquinoline, 5.5 g of 1-(2-methoxyphenyl)piperazine, and 7.6 ml of triethylamine in 100 ml of dimethylsulfoxide was heated at 80° for one hour under argon. The cooled solution was then diluted with water and extracted with methylene chloride. The organic layer was washed with sodium bicarbonate solution, dried over sodium sulfate, charcoaled, and evaporated. The residue was crystallized from ethanol to give 11.1 g of 6,7-dimethoxy-1-{(3,4-dimethoxyphenyl)methyl}-4-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]isoquinoline as a yellow solid, mp 117°-119°.

1. temperaturewas heated at 80° for one hour under argon
2. extractionextracted with methylene chloride
3. washThe organic layer was washed with sodium bicarbonate solution
4. dry with materialdried over sodium sulfate
5. customevaporated
6. customThe residue was crystallized from ethanol