Piperazine → 6-Chloro-4,7-dimorpholino-2-piperazino-pteridine

HRID 638168Notes

Reaction equation

HRID 638168 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[N:5][C:6]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:7]([Cl:18])[N:8]=2)[N:3]=1.[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>O1CCOCC1>[Cl:18][C:7]1[N:8]=[C:9]2[C:4](=[N:5][C:6]=1[N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)[N:3]=[C:2]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[N:11]=[C:10]2[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 13371660HCID 13371660, compound

Product 1

HCID 133716676-Chloro-4,7-dimorpholino-2-piperazino-pteridine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

9.3 g (0.025 mol) of 2,6-dichloro-4,7-dimorpholino-pteridine were refluxed for one hour with 8.6 g (0.1 mol) of anhydrous piperazine in 200 ml of dioxane. The solvent was substantially distilled off, and the residue was digested with about 100 ml of water. After the aqueous mixture stood for a short time, it was suction-filtered, and the filter cake was washed with water and dried at about 70° C.

Workup

  1. distillationThe solvent was substantially distilled off
  2. filtrationwas suction-filtered
  3. washthe filter cake was washed with water
  4. customdried at about 70° C.

Sources & evidence

ORD record
ord-975b39cf88654e70a67234151bab586f
Source dataset
uspto-grants-1985_12
Patent number
US04560685

Reaction notes

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