Methanol → HCID 13371668, compound

HRID 638170Notes

Reaction equation

HRID 638170 reaction equation
[Na].[CH2:2]([NH:9][C:10]1[N:19]=[C:18]2[C:13]([C:14]([N:26]3[CH2:31][CH2:30][S:29](=[O:32])[CH2:28][CH2:27]3)=[N:15][C:16]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:17]2)=[N:12][C:11]=1Cl)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:34][OH:35]>O1CCOCC1>[CH2:2]([NH:9][C:10]1[N:19]=[C:18]2[C:13]([C:14]([N:26]3[CH2:31][CH2:30][S:29](=[O:32])[CH2:28][CH2:27]3)=[N:15][C:16]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:17]2)=[N:12][C:11]=1[O:35][CH3:34])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 13371675HCID 13371675, compound

Product 1

HCID 13371668HCID 13371668, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 0.23 g (0.01 mol) of sodium in 10 ml of methanol was poured into a solution of 2.9 g (0.006 mol) of 7-benzylamino-6-chloro-4-(1-oxido-thiomorpholino)-2-piperazino-pteridine in 100 ml of dioxane. The resulting mixture was refluxed for 30 minutes and then the solvent was substantially distilled off in vacuo. The residue was taken up in about 70 ml of water, and the reaction product which precipitated was suction-filtered off, washed with water and dried at about 60° C.

Workup

  1. temperatureThe resulting mixture was refluxed for 30 minutes
  2. distillationthe solvent was substantially distilled off in vacuo
  3. customthe reaction product which precipitated
  4. filtrationwas suction-filtered off
  5. washwashed with water
  6. customdried at about 60° C.

Sources & evidence

ORD record
ord-6d0344bb689743efa9c3a626862e0676
Source dataset
uspto-grants-1985_12
Patent number
US04560685

Reaction notes

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