HCID 13336325, compound → HCID 20253561, compound

HRID 638185Notes

Reaction equation

HRID 638185 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([NH:6][CH:7]2[CH2:12][CH2:11][N:10](C(OCC)=O)[CH2:9][CH2:8]2)=[C:4]([C:20](=[O:28])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[F:27])[CH:3]=1.Cl.O>>[ClH:1].[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([NH:6][CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[C:4]([C:20](=[O:28])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[F:27])[CH:3]=1

Participants

3

Reactant 2

HCID 13336325HCID 13336325, compoundHCID 21885828Hydrate;hydrochloride

Product 1

HCID 20253561HCID 20253561, compoundYield 190.3%

Procedure

A mixture of said product (6.35 g) obtained in Step (a) and conc.hydrochloric acid-water (1:1) mixture (50 ml) is refluxed over a period of 20 hours. The reaction mixture is concentrated in vacuo to give 4-[4-chloro-2-(2-fluorobenzoyl)anilino]piperidine hydrochloride (5.51 g) as crystals melting at 225° to 228° C.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-7b42797a4d974e338d8264f62d07eee3
Source dataset
uspto-grants-1985_12
Patent number
US04560684

Reaction notes

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