Sulfuric Acid → HCID 20253633, compound

HRID 638210Notes

Reaction equation

HRID 638210 reaction equation
S(=O)(=O)(O)O.[C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[CH:16]=[CH:17][C:18](=[O:24])[NH:19]3)=[CH:10][CH:9]=1)#[N:7].[OH-:25].[NH4+]>>[C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[CH:16]=[CH:17][C:18](=[O:24])[NH:19]3)=[CH:10][CH:9]=1)(=[O:25])[NH2:7]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 20253636HCID 20253636, compound

Product 1

HCID 20253633HCID 20253633, compound

Procedure

To a 35 ml of concentrated sulfuric acid chilled in an ice bath was added 5 g of 5-(4-cyanophenyl)-1,6-naphthyridin-2(1H)-one. The resulting mixture was allowed to stand in an ice bath for 30 minutes and then at room temperature overnight. The mixture was poured onto ice and neutralized by adding aqueous ammonium hydroxide solution. The resulting white precipitate was collected, washed with distilled water, dried in a vacuum oven at 90°-95° C. to yield 4.8 g of 5-(4-carbamylphenyl)-1,6-naphthyridin-2(1H)-one, m.p. >300° C.

Workup

  1. customat room temperature
  2. customovernight
  3. additionThe mixture was poured onto ice
  4. customThe resulting white precipitate was collected
  5. washwashed with distilled water
  6. customdried in a vacuum oven at 90°-95° C.

Sources & evidence

ORD record
ord-6b0df7e86dc8426b8357b1e8bc2b4030
Source dataset
uspto-grants-1985_12
Patent number
US04560691

Reaction notes

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