HCID 178479682, compound → HCID 178478568, compound

HRID 638229Notes

Reaction equation

HRID 638229 reaction equation
[ClH:1].O[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1>S(Cl)(Cl)=O>[ClH:15].[Cl:1][CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 178479682HCID 178479682, compound

Product 1

HCID 178478568HCID 178478568, compoundYield 192.8%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Conditions

Temperature
0 °C

Procedure

12.25 g (0.05 mole) of 4-hydroxymethyl-5-(4-chlorophenyl)-imidazole hydrochloride is added to stirred thionyl chloride (30 ml). The solution is heated to the boiling temperature and stirred for further 2 hours. After cooling to about 0° C. for about 30 min. the reaction mixture is filtered; the solid on the filter is washed with ethyl ether and dried under vacuum to give 12.7 g (yield 96.6%) of 4-chloromethyl-5-(4-chlorophenyl)-imidazole hydrochloride.

Workup

  1. temperatureThe solution is heated to the boiling temperature
  2. filtrationis filtered
  3. washthe solid on the filter is washed with ethyl ether
  4. customdried under vacuum

Sources & evidence

ORD record
ord-84d4cbc588ea4c66b630270a668cf5bd
Source dataset
uspto-grants-1985_12
Patent number
US04560696

Reaction notes

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