HCID 178479682, compound → HCID 178478568, compound

Participants

Reaction Conditions

Reaction Steps

12.25 g (0.05 mole) of 4-hydroxymethyl-5-(4-chlorophenyl)-imidazole hydrochloride is added to stirred thionyl chloride (30 ml). The solution is heated to the boiling temperature and stirred for further 2 hours. After cooling to about 0° C. for about 30 min. the reaction mixture is filtered; the solid on the filter is washed with ethyl ether and dried under vacuum to give 12.7 g (yield 96.6%) of 4-chloromethyl-5-(4-chlorophenyl)-imidazole hydrochloride.

Provenance & Evidence