Water → HCID 14270572, compound

HRID 638239Notes

Reaction equation

HRID 638239 reaction equation
[F:1][C:2](I)([F:4])[F:3].[Cl:6][CH2:7][C:8]([CH2:10][Cl:11])=[O:9].O>CN(C)C=O.[Zn]>[Cl:6][CH2:7][C:8]([C:2]([F:4])([F:3])[F:1])([OH:9])[CH2:10][Cl:11]

Participants

6

Reactant 3

HCID 962WaterHCID 107931,3-DichloroacetoneHCID 16843Trifluoroiodomethane

Product 1

HCID 14270572HCID 14270572, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 6228DimethylformamideSolvent

Procedure

A mixture of commercial zinc powder (1.30 g, 0.02 mole), trifluoromethyl iodide (2.15 g, 11 mmole) and 1,3-dichloroacetone (5.6 g, 44 mmole) in 30 ml dimethylformamide (DMF) is irradiated in the water bath of an ultrasound laboratory cleaner (35 Watts, 32 KHz) for 30 minutes. The mixture is partitioned between 2% w/v aqueous hydrochloric acid and diethyl ether. The ether extract is dried (MgSO4) and the solvent evaporated to afford the title compound.

Workup

  1. customThe mixture is partitioned between 2% w/v aqueous hydrochloric acid and diethyl ether
  2. extractionThe ether extract
  3. dry with materialis dried (MgSO4)
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-ab992913bd134f5f95622df3adc4c6f4
Source dataset
uspto-grants-1985_12
Patent number
US04560697

Reaction notes

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