HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylisonicotinamide → N-methylpiperidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylisonicotinamide | HCID 96707 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-methylpiperidine-4-carboxamide | HCID 2760460 | 98.1% |
Reaction Steps
A mixture of 20 g (0.147 mol) of N-methylisonicotinamide, 100 ml of ethanol, and 1.2 g of platinum oxide was hydrogenated in a Parr shaker at 60° and 60 psi for 8 hr. The catalyst was filtered off, and the filtrate was concentrated in vacuo. The residue was crystallized from ether to give 20.5 g of crude product, mp 115°-121°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04560692 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-7609ca3b91264308ad7fcd434dc646b5 |
| Source note | uspto-grants-1985_12 |