Ethanol → 1-[2-(4-Chlorophenyl)-4-quinolinyl]-4-piperidinecarboxamide

HRID 638268Notes

Reaction equation

HRID 638268 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH:3]=1.[NH:19]1[CH2:27][CH2:26][CH:22]([C:23]([NH2:25])=[O:24])[CH2:21][CH2:20]1.C(O)C>C1(O)C=CC=CC=1>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:4]2[CH:3]=[C:2]([N:19]3[CH2:27][CH2:26][CH:22]([C:23]([NH2:25])=[O:24])[CH2:21][CH2:20]3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 37724-PiperidinecarboxamideHCID 112195464-Chloro-2-(4-chlorophenyl)quinoline

Product 1

HCID 136039141-[2-(4-Chlorophenyl)-4-quinolinyl]-4-piperidinecarboxamide

Reagents, catalysts & solvents 1

HCID 996PhenolSolvent

Procedure

In a manner analogous to that of Example 6, 4-chloro-2-(4-chlorophenyl)quinoline was reacted with isonipecotamide in phenol at 170° C., yielding the named compound, mp. 245°-247° dec., from ethanol.

Workup

  1. customyielding the named compound, mp. 245°-247° dec.

Sources & evidence

ORD record
ord-dfb63a18cc624a76ac643089f08d8317
Source dataset
uspto-grants-1985_12
Patent number
US04560692

Reaction notes

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