反应详情

To a suspension of 36.78 g (0.25 mol) of isatin in 500 ml of ethanol was added 75 ml of 10N sodium hydroxide. After a few minutes of stirring a solid precipitated. To this mixture was added 35 ml (0.286 mol) of p-fluoroacetophenone, and it was stirred and heated under reflux for 1.5 hr. It was then allowed to cool slightly, and acidified with 250 ml of 3N hydrochloric acid. The precipitated solid was collected, washed with water and with ether, and dried to give 50.6 g of crude product, mp 205-215. Recrystallization from ethanol gave 38.8 g of the above-named acid, mp 210°-213° dec.

1. customprecipitated
2. stirringwas stirred
3. temperatureheated
4. temperatureunder reflux for 1.5 hr
5. temperatureto cool slightly
6. customThe precipitated solid was collected
7. washwashed with water and with ether
8. customdried
9. customto give 50.6 g of crude product, mp 205-215
10. customRecrystallization from ethanol