Calcium Carbonate → HCID 20253970, compound

HRID 638316Notes

Reaction equation

HRID 638316 reaction equation
[CH:1]([C:3]1[CH:22]=[CH:21][C:6]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([O-:19])=[O:18])[C:12]3=[CH:11][C:10]=2[Cl:20])=[O:8])=[CH:5][CH:4]=1)=[CH2:2].[K+].C(=O)([O-])[O-].[Ca+2:28].[Cl-].[NH4+].[Ca]>Cl.O>[CH:1]([C:3]1[CH:22]=[CH:21][C:6]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([O-:19])=[O:18])[C:12]3=[CH:11][C:10]=2[Cl:20])=[O:8])=[CH:5][CH:4]=1)=[CH2:2].[Ca+2:28].[CH:1]([C:3]1[CH:22]=[CH:21][C:6]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([O-:19])=[O:18])[C:12]3=[CH:11][C:10]=2[Cl:20])=[O:8])=[CH:5][CH:4]=1)=[CH2:2]

Participants

7

Reactant 4

HCID 10112Calcium Carbonate2×HCID 25517Ammonium ChlorideHCID 5460341CalciumHCID 23671915HCID 23671915, compound2×

Product 1

HCID 20253970HCID 20253970, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

To a solution of 175 mg of 5-(4-vinylbenzoyl)-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml of methanol is added 1 molar equivalent of potassium hydroxide, in the form of a 0.1N solution, thus yielding a solution containing potassium 5-(4-vinylbenzoyl)-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate. A solution of 40 mg of calcium carbonate dissolved in the minimum amount of 1N hydrochloric acid necessary to effect solution of the calcium carbonate, is buffered with 100 mg of solid ammonium chloride, followed by the further addition of 5 ml of water. The thus obtained buffered calcium solution is then added to the solution of potassium 5-(4-vinylbenzoyl)-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate and the precipitate which forms is collected by filtration, washed with water and air dried to yield calcium 5-(4-vinylbenzoyl)-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate.

Workup

  1. customThe thus obtained
  2. filtrationthe precipitate which forms is collected by filtration
  3. washwashed with water and air
  4. customdried

Sources & evidence

ORD record
ord-184cf04b5ddc46a5813283bbd2993a31
Source dataset
uspto-grants-1985_12
Patent number
US04560699

Reaction notes

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