Acetic Anhydride → HCID 22826632, compound

HRID 638326Notes

Reaction equation

HRID 638326 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH:5]([P:16]([OH:28])([CH2:18][CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:17])[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7].[C:29](OC(=O)C)(=[O:31])C>C(O)=O>[CH:29]([NH:1][CH2:2][CH2:3][CH2:4][CH:5]([P:16]([OH:28])([CH2:18][CH2:19][CH2:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:17])[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7])=[O:31]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22826622HCID 22826622, compound

Product 1

HCID 22826632HCID 22826632, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 1 g (2.44 mmol) of (±)-1-[5-amino-2-[hydroxy-(4-phenylbutyl)phosphinyl]-1-oxopentyl]-L-proline (prepared as described in Example 1) in a mixture of 5 ml of acetic anhydride and 15 ml of 90% formic acid is kept at room temperature for 3 hours, then evaporated to give the title product.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-df2c90add6274d039ef6c9073da112ae
Source dataset
uspto-grants-1985_12
Patent number
US04560680

Reaction notes

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