反应详情

A solution of N-(4-methylbenzyl)-9-aza-bicyclo-[3.3.1]-nonan-3-one (5 g), hydroxylamine hydrochloride (1.5 g) and pyridine (0.75 ml) in ethanol (100 ml) was heated at reflux for 1 hour. The solution was evaporated and the residue dissolved in ethyl acetate and water. It was basified with potassium carbonate and the ethyl acetate extract was separated, dried and evaporated to give the crude oxime. Recrystallisation from ethyl acetate/light petroleum gave the oxime (4 g, 77%).

1. temperatureat reflux for 1 hour
2. customThe solution was evaporated
3. dissolutionthe residue dissolved in ethyl acetate
4. extractionthe ethyl acetate extract
5. customwas separated
6. customdried
7. customevaporated
8. customto give the crude oxime
9. customRecrystallisation from ethyl acetate/light petroleum