反应详情

温度

20 °C

72.2 g of 6-bromo-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonyl chloride are dissolved in 200 ml of tetrahydrofuran and the solution is added dropwise to 122.6 ml of a 30% aqueous solution of ammonia. The mixture is stirred for 30 minutes at 20° C. and concentrated under reduced pressure at 45° C. The residue is triturated with ether. The precipitate so obtained is isolated, washed with water and dried at 45° C., affording 44.6 g of 6-bromo-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonamide.

1. concentrationconcentrated under reduced pressure at 45° C
2. customThe residue is triturated with ether
3. customThe precipitate so obtained
4. customis isolated
5. washwashed with water
6. customdried at 45° C.