Triethylamine → HCID 54391070, compound

HRID 638403Notes

Reaction equation

HRID 638403 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]([NH2:15])([CH:12]([F:14])[F:13])[CH2:5][CH2:6][CH2:7][NH:8][C:9](=[O:11])[CH3:10].[C:17](Cl)(=[O:20])[CH2:18][CH3:19].C(N(CC)CC)C>CCOCC>[CH3:1][O:2][C:3](=[O:16])[C:4]([CH:12]([F:14])[F:13])([NH:15][C:17](=[O:20])[CH2:18][CH3:19])[CH2:5][CH2:6][CH2:7][NH:8][C:9](=[O:11])[CH3:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 54162195HCID 54162195, compound

Product 1

HCID 54391070HCID 54391070, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 0.47 g of 5-acetylamino-2-amino-2-difluoromethylpentanoic acid methylester in 10 ml of ether is added simultaneously at 0° C. 0.18 g of propionylchloride and 0.2 g of triethylamine. The reaction mixture is stirred at room temperature for 2 hours then extracted with ethylacetate. The organic phase is washed with a solution of sodium bicarbonate, water, then brine and dried over magnesium sulfate. Evaporation of the solvent gives 5-acetylamino-2-difluoromethyl-2-propionylaminopentanoic acid methylester.

Workup

  1. extractionthen extracted with ethylacetate
  2. washThe organic phase is washed with a solution of sodium bicarbonate, water
  3. dry with materialbrine and dried over magnesium sulfate
  4. customEvaporation of the solvent

Sources & evidence

ORD record
ord-9d82cc80de9249ddb0d50160511b5c73
Source dataset
uspto-grants-1985_12
Patent number
US04560795

Reaction notes

Loading…