Hydrochloric Acid → HCID 53923779, compound

HRID 638436Notes

Reaction equation

HRID 638436 reaction equation
[CH3:1][NH:2][C:3](=[S:17])[NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[O:16])[C:11]([O:13]CC)=[O:12])[N:9]=1.CNC(=S)NC1NC(C(=O)C(OCC)=O)=CS1.[OH-].[Na+].Cl>O.C(O)C>[CH3:1][NH:2][C:3](=[S:17])[NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[O:16])[C:11]([OH:13])=[O:12])[N:9]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54335615Ethyl 2-[[(methylamino)thioxomethyl]amino]-α-oxo-4-thiazoleacetateHCID 86738140HCID 86738140, compound

Product 1

HCID 53923779HCID 53923779, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a mixture of ethyl 2-[2-[3-(methyl)thioureido]-1,3-thiazol-4-yl]glyoxylate, which can be represented as ethyl 2-[2-[3-(methyl)thioureido]-2,3-dihydro-1,3-thiazol-4-yl]glyoxylate, (21 g.), ethanol (200 ml.) and water (100 ml.) was added 1N sodium hydroxide aqueous solution (154 ml.) under ice-cooling and stirring. The mixture was further stirred for 10 minutes and then neutralized with 1N hydrochloric acid (154 ml.). The precipitates were collected by filtration, washed with water and then dried to give 2-[2-[3-(methyl)thioureido]-1,3-thiazol-4-yl]-glyoxylic acid, which can be represented as 2-[2-[3-(methyl)-thioureido]-2,3-dihydro-1,3-thiazol-4-yl]glyoxylic acid, (17.8 g.), mp.>250° C.

Workup

  1. temperaturecooling
  2. stirringThe mixture was further stirred for 10 minutes
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-ba0b61bd6084425d8ab4c8f5aeb79855
Source dataset
uspto-grants-1985_12
Patent number
US04560765

Reaction notes

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