2,5-Dimethylpiperazine → HCID 4400191, compound

HRID 638466Notes

Reaction equation

HRID 638466 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][CH:5]([CH3:8])[CH2:4][NH:3]1.[C:9](Cl)(=[O:13])[CH2:10][CH2:11][CH3:12]>>[C:9]([N:3]1[CH2:4][CH:5]([CH3:8])[N:6]([C:9](=[O:13])[CH2:10][CH2:11][CH3:12])[CH2:7][CH:2]1[CH3:1])(=[O:13])[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 78162,5-DimethylpiperazineHCID 8855Butyryl chloride

Product 1

HCID 4400191HCID 4400191, compoundYield 446.2%

Procedure

The reaction of 5 g (0.044 mole) of 2,5-dimethylpiperazine with 12.15 g (0.0114 mole) of butyryl chloride is conducted as described in Example III, and the crude product obtained is an oily solid. The solid is washed with hexane, recrystallized from hexane/acetone, and dried in vacuo for 16 hours at 55° C. over phosphorus pentoxide to yield 6.47 g of 1,4-dibutryl-2,5-dimethylpiperazine: mp, 92°-94° C., as confirmed by IR and NMR spectroscopic analysis.

Workup

  1. customthe crude product obtained
  2. washThe solid is washed with hexane
  3. customrecrystallized from hexane/acetone
  4. dry with materialdried in vacuo for 16 hours at 55° C. over phosphorus pentoxide

Sources & evidence

ORD record
ord-d25574bc48ab4f22a6afb792af88dbff
Source dataset
uspto-grants-1985_12
Patent number
US04561451

Reaction notes

Loading…