2-Fluorobenzoyl chloride → HCID 20252610, compound

Participants

Reaction Steps

To a mixture of 35 g (0.36 moles) ethoxyamine hydrochloride, 51 g (0.37 moles) potassium carbonate and ice chips (about 100 g) which had been stirred for several minutes, 50 g (0.32 moles) 2-fluoro-benzoylchloride in methylene chloride (about 50 ml) were added dropwise. The reaction mixture was allowed to come to room temperature and then was stirred at room temperature for about three to four hours. The aqueous and methylene chloride layers were separated. The methylene chloride layer was dried with magnesium sulfate, filtered and stripped under reduced pressure to give about 82 g of the above-identified product as a clear light yellow liquid.

Provenance & Evidence