2-Fluorobenzoyl chloride → HCID 20252610, compound

HRID 638530Notes

Reaction equation

HRID 638530 reaction equation
Cl.[CH2:2]([O:4][NH2:5])[CH3:3].C(=O)([O-])[O-:7].[K+].[K+].[F:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](Cl)=[O:16]>C(Cl)Cl>[CH2:2]([O:4][N:5]([C:15](=[O:16])[C:14]1[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=1[F:12])[OH:7])[CH3:3]

Participants

5

Reactant 3

HCID 98082-Fluorobenzoyl chlorideHCID 11430Potassium CarbonateHCID 76850O-ethylhydroxylamine hydrochloride

Product 1

HCID 20252610HCID 20252610, compoundYield 128.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 35 g (0.36 moles) ethoxyamine hydrochloride, 51 g (0.37 moles) potassium carbonate and ice chips (about 100 g) which had been stirred for several minutes, 50 g (0.32 moles) 2-fluoro-benzoylchloride in methylene chloride (about 50 ml) were added dropwise. The reaction mixture was allowed to come to room temperature and then was stirred at room temperature for about three to four hours. The aqueous and methylene chloride layers were separated. The methylene chloride layer was dried with magnesium sulfate, filtered and stripped under reduced pressure to give about 82 g of the above-identified product as a clear light yellow liquid.

Workup

  1. customto come to room temperature
  2. stirringwas stirred at room temperature for about three to four hours
  3. customThe aqueous and methylene chloride layers were separated
  4. dry with materialThe methylene chloride layer was dried with magnesium sulfate
  5. filtrationfiltered

Sources & evidence

ORD record
ord-228b2ec51bb74240bfa11ec660ae3d73
Source dataset
uspto-grants-1985_12
Patent number
US04562180

Reaction notes

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