反应详情

3.4 g (0.02 mole) of 4-chlorothieno[2,3-d]pyrimidine, 4.4 g (0.02 mole) of 2-(2-methyl-4-pentylphenoxy)ethylamine and 2 g (0.02 mole) of triethylamine were dissolved in 50 ml of toluene, and the solution was heated under reflux for 4 hours. At the end of this time, water was added to the reaction mixture, and the mixture was then extracted with toluene. The extract was dried over anhydrous sodium sulphate, and the solvent was distilled off, after which the residue was recrystallised from a mixture of toluene and hexane, to give 5.4 g (yield 76%) of the title compound in the form of colourless crystals melting at 93°-95° C.

1. temperaturethe solution was heated
2. temperatureunder reflux for 4 hours
3. extractionthe mixture was then extracted with toluene
4. dry with materialThe extract was dried over anhydrous sodium sulphate
5. distillationthe solvent was distilled off
6. customafter which the residue was recrystallised from a mixture of toluene and hexane